This study is premised against the background that there is an increasing global attention to the threats of open defecation to human health, dignity and the environment and open defecation facilitates the transmission of infectious diseases like diarrhea, typhoid, cholera and other diseases associated with poor sanitation, hygiene and waste management. To help address the health concerns and ameliorate the spread of these diseases in Nigeria, the Federal Government and other International Development Partners like UNICEF began the Open- Defecation – Free (ODF) campaign messages in the country. ODF messages aimed at providing adequate information and awareness on the negative effects of open defecation practice and to sensitise the people to adopt behavioral change of saying no to open defecation practice but rather use the toilet to achieve an ODF environment. In all these, it is not clear if the residents of Anambra State, one of the pilot States in ODF messages and campaign in Nigeria representing the South East Zone are favorably disposed to these awareness and behavioural change messages and interventions. This circumstance therefore motivated the study titled “Open-Defecation-Free Messages: A knowledge, Attitude and Practice (KAP) Study of Residents of Anambra State” which set the following objectives; to determine whether respondents in Anambra State have knowledge of ODF messages, to ascertain the respondents’ sources of information about ODF messages, to ascertain the respondents’ sources of information about ODF messages, to determine whether there is a significant relationship between knowledge of ODF messages and the respondents’ attitude towards these messages, to find out whether there is a significant relationship between respondents’ attitudes to ODF messages and the practice of these messages, and to determine whether respondents in Anambra State advocate for ODF practice after exposure to ODF messages.